Modification of EBV Associated Lymphomagenesis and Its Immune Control by Co-Infections and Genetics in Humanized Mice

Epstein Barr virus (EBV) is one of the most successful pathogens in humans with more than 95% human adult population persistently infected. EBV infects only and threatens these its potent growth transforming ability that readily allows for immortalization B cells culture. Accordingly, it also found around 1-2% tumors, primarily lymphomas epithelial cell carcinomas. Fortunately, however, our immune system has learned to control this tumor carriers, requires modification associated lymphomagenesis by either co-infections, such as malaria, Kaposi sarcoma herpesvirus (KSHV) immunodeficiency (HIV), or genetic predispositions positive tumors emerge. Some can be modelled humanized mice that, therefore, provide a valuable platform test curative immunotherapies prophylactic vaccines against pathologies.